On the afternoon of September 22, 2024, an engaging NFL contest is set as the Detroit Lions go head-to-head with the Arizona Cardinals at State Farm Stadium in Glendale, with the kickoff slated for 4:25 PM.

The Detroit Lions currently hold a middle-of-the-pack position in their division, ranked 2nd, and are 9th in their conference with a balanced record of 1-1-0, translating to a .500 winning percentage. They have accumulated 42 points for while conceding 40 points against, resulting in a positive net differential of 2 points.

Similarly, the Arizona Cardinals find themselves 2nd in their division and 7th in their conference, also sporting a 1-1-0 record with a .500 win rate. Their offensive output stands at 69 points, contrasted by 44 points allowed, affording them a net point differential of 25 points.

In their previous outing, the Lions were narrowly defeated 16-20 by Tampa Bay at Ford Field, tallying 26 first downs and amassing 139 rushing yards alongside 324 passing yards. On the flip side, the Cardinals dominated their last game against the LA Rams at home, cruising to a 41-10 victory. They recorded 24 first downs with a robust 231 rushing yards and 258 passing yards.

Quarterback performances are set to be a focal point with Detroit’s Jared Goff throwing for 307 yards in their last game, albeit without a touchdown, finishing with a passer rating of 61.7. Arizona’s Kyler Murray, however, had a stellar game, passing for 266 yards, delivering 3 touchdowns, and achieving a perfect passer rating of 158.33.

Odds Analysis: Heading into this matchup, betting odds reflect anticipation of a closely contested battle. The Arizona Cardinals are favored with a point spread of 4.5 points indicating expectations of a home field advantage influencing the outcome. Conversely, for those backing the Detroit Lions, the point spread is set at -4.5. The game’s total points line is projected at 51.5, offering insights into expected overall scoring. Moneyline bets show the Cardinals at +185, suggesting moderate confidence from oddsmakers, while the Lions are marked at -225, favored to clinch the win. These odds form a critical part of the strategy for sports bettors looking into this NFL fixture.